I usually have one tote as my "purse," and carry the stuff below, but I also try to carry-on my other bag. I don't pack a lot of stuff since I usually travel by myself, and really don't carry if I wear the same basic outfits over and over (I do wash them!).

So shampoo and stuff like that I keep in my larger bag/carry-on.
Passport
Travel journal/pens
Rx and ibuprofen
Cold-eeze (I never travel w/out this stuff)
Vitamins
Cell phone/charger
Digital camera/memory cards, etc.
As many books as I can cram in. I read fast, and usually go through 2-3 books on a long flight.
Sunglasses
Wallet
Clip-on book light
Gum
Bottle of water
Reading glasses (several pairs)
Hand cream
Lip balm
Toothbrush and toothpaste
Makeup
iPod and accessories
Other travel documents (i.e., ticket, boarding pass)
Guidebooks and/or phrase books
Maps
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Mardee
Travels in Turkey 2007
Easter in Italy
It's a dangerous business, Frodo, going out your door. You step onto the road, and if you don't keep your feet, there's no knowing where you might be swept off to. ~J.R.R. Tolkien